Breathing Space London

mindfulness for health

Research into benefits of meditation on mental healthPicture of person after meditating

The following is a summary, compiled by Breathing Space, of recent research into the positive effects of meditation on mental health.

1. Introduction

There have been quite a few studies done on whether there is a measurable effect  on a person's brain  during and following meditation practice. What follows is a summary of  the information found in medical publications and press releases, which details some of the findings on the effects of meditation. It is by no means an exhaustive list of all the research carried out to date, but should give some indication of the many and varied changes regular meditation can have.  One notable effect of meditation that has been observed in neuroscience studies is that practiced meditators show marked development in the areas of the brain associated with well being.15  This information is particularly relevant in today's world, as recent studies have shown that while income and economic comfort increase in the Western world, well being and happiness do not.    

2. Results from Medical Investigations

2.1. General anatomical regions of the brain shown to be affected during meditation

Regions of the brain:

Studies have shown that meditation can have a positive effect on the left prefrontal cortex, which is associated with positive emotional states, and is thought to help in minimizing the emotional response to an unpleasant experience. 14  For example, in people who had completed an eight week course in mindfulness meditation, the left prefrontal cortex was found to be more active when compared with a control group. 16  Regular meditation has also been shown to increase the thickness of this region of the brain.   This is particularly relevant for people who suffer from depression, as they tend to have lower levels of activity in the prefrontal cortex, and in fact, the severity of a person's depression has been linked to the degree to which activity has been reduced in that area. 14

Meditation also affects activity in the amygdala, which is involved in processing emotional stimuli, and has some control over the physical response in the nervous system, and influences whether the parasympathetic or sympathetic nervous system is more active.  These two major components of the nervous system have opposite roles.  Activation of the parasympathetic system results in lower amounts of stress hormones, while the sympathetic system primes the body for a "fight or flight" response. .  Studies have shown that during meditation there is stimulation of the right lateral amygdala, which results in stimulation of the peripheral parasympathetic nervous system.21  Normally, the sympathetic nervous system is more active than the parasympathetic nervous system.  However, in EEG studies (see Section 2.3.1) meditation seems to reverse the roles of these two major components of the nervous system, resulting in lowered activity in the sympathetic nervous system and raised activity in the parasympathetic nervous system and therefore decreased heart rate, lowered blood pressure and decreased respiratory rates(see Section 2.2).20, 21 

Further to this, during a study by neural researchers into mindfulness, it was found that the more mindful a person was, the more activation there was in the "labeling" area of the brain (the region used when we name things) and less activity in the amgydala in areas affecting the sympathetic nervous system, resulting in a reduced response of this system.26 . Some studies have also shown increased activity in the hippocampus, which is important in memory formation, and also in a part of the limbic system, which has  close functional connections with the hypothalamus.  The hypothalamus is involved in the emotional processing of thirst, hunger, circadian rhythms and control of the autonomic nervous system.21 

There also seems to be an increase in cortical thickness as a result of meditation. Generally the cortex becomes thinner with age5, however, meditation appears to produce an increase in cortical thickness, especially in areas related to emotional processing.14, 18  More specifically, an increase in thickness has been seen after five months of starting meditation, particularly in the left prefrontal cortex area (associated with positive emotions).  Research has also suggested that the increase in cortical thickness is proportionally related to how long a person has been meditating. 14  

2.2. Effects on the nervous system and neurochemicals released in the brain

As mentioned above, studies have shown that during meditation there is stimulation of the right lateral amygdala, which results in stimulation of the peripheral parasympathetic nervous system.  Activation of the parasympathetic nervous system results in lower blood pressure, decreases in heart and respiratory rates and these are also seen during meditation. 20, 21  Regular practice appears to reverse the roles of the parasympathetic and sympathetic nervous systems. 20, 24  Increased activity in the parasympathetic nervous system also results in decreased production of norepinephrine (also known as noradrenaline, which governs the fight or flight response) and increases in serotonin.  Serotonin is important in regulating mood, and low levels can lead to depression.  Serotonin can stimulate increased production of acetylcholine (involved in memory mechanisms and attention), and can also lead to decreased levels of cortisol (a stress hormone).21   

2.3. Brain Scan Results

2.3.1. EEG Studies

An EEG measures the electrical activity within the brain.  There are five main types of electrical waves seen in EEG brain scans. These are alpha (freq. 8-12 Hz), beta (freq. 12-30 Hz), theta (freq. 4-7 Hz), gamma (freq. 34 - 100+ Hz) and delta (freq. up to 3 Hz).  Alpha waves are associated with general focused attention, relaxation and calmness; Theta waves with quiet focus, relaxation and calmness, memory, spatial navigation, creativity, and problem solving; Beta waves with highly focused attention and busy or anxious thinking; gamma with certain cognitive (e.g. perception) or motor functions; and delta waves with slow wave sleep in adults.  Most of the cerebral signal observed in the scalp EEG falls in the range of 1-20 Hz.

An EEG study has shown that meditation can have long term effects on the types of electrical activity within the brain. The results of a study of long term Buddhist meditators showed sustained high amplitude gamma band and phase synchrony while meditating, and that after meditation, the gamma activity remained higher than the pre-meditation baseline .4 Gamma waves denote intense focus and are usually weak, but these were particularly high in the left prefrontal cortex for experienced meditators.20

In normal activity, brain waves are of the beta type.  However, during meditation, there is a shift in brain activity, with alpha waves the most commonly observed.  Alpha waves produce changes in the autonomic nervous system which result in a calming effect,20  due to the fact that an increase in alpha wave activity is associated with activation of the parasympathetic nervous system.24

EEG studies have also shown an increase in cortical coherence, along with greater left-right brain interaction.   Observing cortical coherence via EEG can be used to evaluate the functionality of cortical connections, and can also provide information about the synchronization of regional cortical activity.  An increase in melatonin production has also been observed during meditation, which enhances the immune system, acts as an antioxidant and helps to regulate the body's circadian rhythm. 21

Results of another EEG study found that that there may also be a relationship between theta and alpha activity and states of internalised attention and positive emotions, both of which are cultivated by vipassana and mindfulness meditation.8  While using Zen meditation, for example, increases were observed in fast theta power and slow alpha power, predominantly evident in the frontal area of the brain.2

2.3.2. MRI Studies

An MRI study for assessing cortical thickness in 20 people with extensive meditation experience found that brain regions associated with attention, interoception (one's sensitivity to stimuli originating inside of the body) and sensory processing, including the prefrontal cortex and right anterior insula, were thicker than for control participants .5  Other results from fMRI studies have shown that during meditation, signal increases are seen in  the dorso lateral prefrontal and parietal cortices, the hippocampus/parahippocampus, and cingulated cortex , all of which are involved in attention and control of the autonomic nervous system.9

Another MRI study has also shown that the practice of mindfulness can help to calm the brain's emotional centre,17 and measuring activity in the frontal region of the brain has shown that  Buddhist meditation can help to shift the brain into more positive mental states.25

2.3.3. Regional Cerebral Blood Flow (rCBF)

People with depression tend to show lower blood flow in the prefrontal region, and the degree to which this is true shows a correlation with the severity of an individual's depression.14 During meditation, a complex pattern of rCBF has been observed, including an increase in rCBF in the prefrontal region, which may reflect increased concentration.13 One research study observed changes in the cingulated gyrus (which relates to emotional function, and is probably a key structure in modulating mood), the dorsolateral prefrontal cortex (relating to working memory), and the thalamus (involved in sensory and motor function).13

2.4. Psychological Effects

In looking at the physical effects of several illnesses, depression was shown to have a greater impact on sufferers than angina, arthritis, asthma and diabetes.22, 27  There is evidence that new generation anti depressants do not have much clinical benefit for most people with depression, however, talking therapies, exercise referral and other treatments can be quite effective.19  In addition, some psychologically based investigations have provided evidence of the positive effects that meditation can have.  As one researcher stated, "one of the most outstanding features of emotion is the pronounced variability among individuals in their reactions to incentives and in their dispositional mood.  Collectively these individual differences have been described as affective style.  A resilient affective style is associated with high levels of left prefrontal activation, changes in activation in the amygdala and a fast recovery of response to negative and stressful events."1 As mentioned previously, there is substantial evidence that meditation has a positive effect in these areas of the brain.

An 8 week stress reduction program based on mindfulness meditation found that participants experienced a significant decrease from baseline figures for reporting daily hassles (24%), psychological distress (44%) and medical symptoms (46%) which were maintained at a 3-month follow up as compared to a control group.3  In addition, a study involving a group of 90 people who suffer from chronic pain  who were on a 10-week programme in mindfulness meditation showed statistically significant reductions in measurements of present moment pain, negative body image, inhibition of activity by pain, pain symptoms, mood disturbances and psychological symptomology such as anxiety and depression.6  Although derived from a small number of studies, results suggest that Mindefulness Based Stress Reduction , specifically, may help a broad range of individuals cope with their clinical and non-clinical problems.10 Mindfulness Based Cognitive Therapy, as used in courses run by the LBC, seems to help reduce the likelihood of further attacks of depression in over 50% of cases so far trialed.18

2.5. Miscellaneous Other Results

Meditation has also been found to help with mood disorders, depression, and behaviors such as anorexia and bulimia,23 as well as with  attention related issues. For example, it can help to increase attention span,7 with one study commenting that mindfulness training may improve attention-related behavioral responses by enhancing the function of specific subcomponents of attention,11 and another observing that there was an activation in the neural structures involved in attention generally.9

Looking at physiological responses, including systolic blood pressure and heart rate, one investigation found that meditation may be associated with lower activation of these physiological responses than seen in eyes-closed rest.12 Meditation also appears to be good for the immune system.  After an influenza vaccine, an increase in antibody titers was observed during mindfulness meditation and appeared to be proportional to the increase in left prefrontal brain activity produced during meditation.28

There also can be an effect on the response of nerves to stimuli. Evoked Potentials (EPs) measure the speed and amplitude of response of nerves to stimulation.  Meditation seems to produce decreased amplitudes and latency for sensory EPs. The time between stimulation and response is called the latency - shorter latencies imply quicker passage of signals along nerves.21

Further to this, it should also be mentioned that significant positive results have been found from using vipassana meditation in a clinical context when treating drug addiction, alcoholism and smoking.29, 30,

3. References

1) Title:  Well-being and affective style: neural substrates and biobehavioural correlates

Author:  Richard J. Davidson

Source: Philosophical Transactions of the Royal Society B, Vol. 359, Number 1449, September 29 2004

2) Title: Changes in EEG and autonomic nervous activity during meditation and their associated personality traits

Author(s): Tetsuya Takahashi, Tetsuhito Murata, Toshihiko Hamada et al

Source:  International Journal of Psychophysiology Vol.55, Issue 2, February 2005, p. 199-207

3) Title: Evaluation of a Wellness-based Mindfulness Stress Reduction Intervention: A Controlled Trial

Author(s): K.A.Williams, M.M.Kolar, B.E.Reger, J.C.Pearson

Source: American Journal of Health Promotion, Vol.15, Issue 6 (July 2001),pp.422-432

4) Title:  Long-term meditators self-induce high-amplitude gamma synchrony during mental practice

Author: Antione Lutz, L.L Greischar, N.B. Rawlings et al


5) Title:  Meditation experience is associated with increased cortical thickness

Author: S.W. Lazar, C.E..B Kerr, R.H.Wasserman et al

Source: Neuroreport 16(17): 193-197,November 28,2005

6) Title:  The clinical use of mindfulness meditation for self-regulation of chronic pain

Authors:  J. Kabat-Zinn, L. Lipworth, R. Burney

Source: Journal of Behavioural Medicine Vol 8, Number 2, p.163-190 (1985)

 7) Title:  Meditation May Make Information Processing in the Brain More Efficient

Author  n/a

Source: web page

Relates to published article "Mental training affects distribution of limited

brain resources" PLOS Biology June 2007, Helen A. Slagter, Antione Lutz et


8) Title:  Human anterior and frontal midline theta and lower alpha reflect positive state and internalised attention: high resolution EEG investigation of meditation.

Author: L.I. Aftanas, S.A. Golocheikine

Source Neuroscience letters, Vol 310, Issue 1, 7 September 2001, Pages 57-60

9) Title: Functional Brain mapping of the relaxation response and meditation

Authors: S.W.Lazar, G.Bush, R.L. Gollub et al

Source: Neuroreport  11(7):151-155, May 15 2000

10) Title:  Mindfulness-based stress reduction and health benefits A meta analysis

Authors: P.Grossman, L. Niemann et al

Source: Journal of Psychosomatic Research, Vol 57, Issue 1, Pages 35- 43

11) Title:  Mindfulness Training Modifies Subsystems of Attention

Authors: A.P.Jha, J. Krompinger, M.J. Baime

Source: Cognitive, Affective & Behavioural Neuroscience, Vol 7 Number 2, June2007 pp.109-119 (11)

12) Title: physiological responses during meditation and rest

Author: M.M. Delmonte

Source: Applied Psychophysiology and Biofeedback, Vol 9, No.2, Jun 1984.

13) Title: The measurement of regional cerebral blood flow during the complex cognitive task of meditation: a preliminary SPECT study

Author: A. Newberg

Source: Psychiatry Research: Neuroimaging, Volume 106, Issue 2, Pages 113-122

14)  Title: A meditation on the brain's duality: the influence of meditation on the brain and mind

Author:Maggie Simon


15)  Title:   Beyond Happiness: deepening the Dialogue Between Buddhism, Psychotherapy and the Mind Sciences

Author: Gay Watson

Source/Publication:  Beyond Happiness: deepening the Dialogue Between Buddhism, Psychotherapy and the Mind Sciences by Gay Watson  (extract)

16) Title:  Meditation 'good for brain'

Author:  N/A

Source/Publication:  BBC NEWS website Wednesday 5th February 2003

17) Title: Brain scans reveal why meditation works

Author: Melinda Wenner

Publication/Source: Yahoo! News ( meditationworks)

18) Title: Scientists probe meditation secrets

Author:  Naomi Law


19) Title:  Anti-depressants 'little effect'

Author: N/A

Source/Publication:  BBC NEWS website 26th February 2008

20) Title: Brain Waves in Meditation

Author: Amy Barnfield


21) Title: Meditation the Future Medication

Author:  Dr. Avdesh Sharma

Source:   Royal College of Psychiatrists (website address):

22) Title: "Depression more harmful than angina"

Author:    Alok Jha

Publication/Source:  The Guardian Friday September 7 2007

23) Title: In the Classroom, a New Focus on Quieting the Mind

Author:  Patricia Leigh Brown

Publication/Source:        New York Times June 16 2007

24) Title: "Mind Over Matter"

Author: Andy Darling

Publication/Source: The Guardian 18.03.2008

25) Title: Studying the Well-Trained Mind

Author: Marcia Barinaga

Publication/Source: 3 October 2003 Vol 302 SCIENCE

26) Title: The Science of Mindfulness Meditation

Author: Psych Central New Editor

Publication/Source: PyschCentral (

27) Title: Depression is a more disabling condition than angina, arthritis, asthma

and diabetes, World Health Organisation research shows

Author: N/A


28) Title:  Alterations in Brain and Immune Function Produced By Mindfulness Meditation

Authors: R.J.Davidson, J. Kabat-Zinn, J. Schumacher et al

Source: Psychosomatic Medicine 65:564 - 570 (2003)

29) International Journal of addictions 1977: 12 :729-54 Ibid

30) International Journal of addictions 1991; 26: 23-325 Ibid

31) = Bulletin of society of psychologists in addictive behaviours 1977;12:729-54 Ibid.